Muralidhar L. Hegde, PhD, F-ABAP
Associate Professor, Department of Neurosurgery
Center for Neuroregeneration
Houston Methodist
Genome damage and defective repair are etiologically linked
to neurodegeneration and brain hemorrhage. However, the specific mechanisms
involved and their implications remain enigmatic, a roadblock for developing
effective mechanism-based therapies. Our recent studies (Wang et al, Nature
Communications, 2018; Mitra et al, PNAS, 2019; Guerrero et al, Hum
Mol Gent, 2020; Dharmalingam et al, ACS Nano, 2020) uncovered novel
mechanisms of DNA repair defects in motor neuron disease amyotrophic lateral
sclerosis (ALS) and brain hemorrhage (ICH) patients, paving the way for DNA
repair-targeted therapies to prevent or slow down disease progression. This
research is supported by National Institutes of Health and Houston Methodist.
Recorded in the Houston Methodist Research Institute Ernest
H. Cockrell Boardroom R2-311 on Wednesday, September 2, 2020.