Vaccines have a major impact on public health and are crucial for improving overall health and prolonging life. However, for many infectious diseases, vaccines are either not yet available or have only short-term efficacy. Despite the BCG vaccine, tuberculosis kills millions of people each year. Dr. Jagannath and his team have discovered that inducing autophagy during vaccine antigen processing in macrophages and dendritic cells enhances vaccine efficacy and long-term protection. Dr. Jagannath’s team is currently exploring how engineering autophagy during vaccines development induces the capability of live attenuated bacterial vaccines and attenuated viral mucosal vaccines to strengthen vaccine-induced protection. Recorded in the Houston Methodist Research Institute Ernest H. Cockrell Boardroom R2-311 on Thursday, June 13, 2019 Timestamps: 3:53 - 6:25 Introduction - Dr. Musser 6:25 - 59:40 Lecture - Dr. Jagannath 59:40 - 1:03:40 - Q&A Introduction by: James M. Musser, MD, PhD Chair, Department of Pathology & Genomic Medicine Fondren Presidential Distinguished Chair, Research Institute Professor of Pathology and Genomic Medicine, Institute for Academic Medicine Director, Center for Molecular & Translational Human Infectious Diseases Research Houston Methodist Weill Cornell Medical College