Targeting Adaptive Immune System in Alzheimer's Disease by Alireza Faridar, MD 10.6.20
From Ibukun Ifelayo on October 6th, 2020
Recent findings, including the discovery of risk genes involved in inflammation signaling, indicate that inflammation is critical for the onset and progression of Alzheimer Disease. Regulatory T cells (Tregs) play an important neuroprotective role in suppressing microglia/macrophage-mediated inflammation, as well as modulating adaptive immune reactions. A progressive compromise in the immunomeulatory function of Tregs occurs through the course of Alzheimer disease. Recovering the immunosuppressive capacity of Tregs may serve as a potential immunotherapy to treat Alzheimer pathology.
Recorded in the Houston Methodist Research Institute Ernest H. Cockrell Boardroom R2-311 on Tuesday, October 6, 2020.
Introduction provided by Dr. Stanley Appel, MD, Peggy & Gary Edwards Distinguished Endowed Chair, Stanley H. Appel Department of Neurology, Co-Director, Neurological Institute, Houston Methodist