Hong Zhao, MD, PhD - Cellular Plasticity in Brain Metastasis from Triple-negative Breast Cancer 06.22.20
From Ibukun Ifelayo on June 23rd, 2020
Hong Zhao MD, PhD
Assistant Professor of Molecular Biology in Oncology
Co-Director of Advanced Cellular and Tissue Microscope Core
Houston Methodist Cancer Center
Up to 40% of patients with cancer develop brain metastases, mostly at the advanced disease stage. However, brain metastases are consistently found with increased frequency in early stage triple negative breast cancer (TNBC) patients, indicating an innate ability of TNBC tumor cells to adapt to the brain. Dr. Zhao’s research focuses on exploring the cellular plasticity of TNBC tumor cells in mediating their colonization and outgrowth in the brain. Her research also integrates knowledge and methods from both neuroscience and cancer to characterize pro- and anti-metastatic molecular mechanisms in brain astrocytes. Further, she leverages powerful predictive computational modeling to investigate and delineate the complex tumor-niche interactions.
Recorded in the Houston Methodist Research Institute Ernest H. Cockrell Boardroom R2-311 on Monday, June 22, 2020.